Tycho Brahe (December 14, 1546 – October 24, 1601)

Famous as an alchemist and astronomer, Brahe’s pioneering observations of planetary motion paved the way for Sir Isaac Newton to develop the theory of gravity.

Unfortunately brilliance and common sense do not always go hand in hand, the manner of his death being the case in point. Known to have a weak bladder and knowing that it was very bad form to leave the banquet table before the festivities concluded, Brahe still neglected to relieve himself before dinner. To compound
matters, he was known to drink excessively, and this particular banquet was no exception. Too polite to ask to be excused, his bladder strained causing a protracted (11 day), agonizing death. Whether he died of a burst bladder or hyponatremia (low levels of sodium in the blood) or mercury poisoning is now debated.
Note: this is very similar to an event in which a lady died recently in a competition entitled “Hold Your Wee for a Wii”. She died of hyponatremia.